Trevor Fidler, PhD

Principal Investigator
Cardiovascular Research Institute
[email protected]
+1 415 514-8082

Dr. Fidler obtained his PhD from the University of Utah under the supervision of Dr. E. Dale Able. His work focused on understanding how bioenergetic metabolism alters platelet function in thrombosis and inflammatory conditions. Dr. Fidler then moved to Columbia University to work with Dr. Alan Tall on understanding how dysfunctional hematopoiesis promotes atherosclerosis. Dr. Fidler then moved to UCSF in the summer of 2023 to start the Fidler Lab focused on understanding how dysfunctional hematopoiesis and genetic risk factors can promote cardiovascular disease.

Publications: 

An epigenetic switch in macrophages promotes fibrosis in the failing heart.

Nature cardiovascular research

Tall AR, Fidler TP

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis.

Nature cardiovascular research

Fidler TP, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, Abramowicz S, Xiao T, O'Connor K, Sachs N, Wang N, Maegdefessel L, Levine R, Reilly M, Tall AR

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk.

The Journal of clinical investigation

Yu Z, Filder TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.

Arteriosclerosis, thrombosis, and vascular biology

Sonkar VK, Eustes AS, Ahmed A, Jensen M, Solanki MV, Swamy J, Kumar R, Fidler TP, Houtman JCD, Allen BG, Spitz DR, Abel ED, Dayal S

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis.

The Journal of clinical investigation

Liu W, Östberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, Hou X, Xiao T, Fidler TP, Abramowicz S, Yang YG, Soehnlein O, Tall AR, Wang N

Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein.

Scientific reports

Yalcinkaya M, Liu W, Islam MN, Kotini AG, Gusarova GA, Fidler TP, Papapetrou EP, Bhattacharya J, Wang N, Tall AR

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.

Circulation

Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis.

Nature

Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, Liu W, Thomas DG, Hajebrahimi MA, Pircher J, Silvestre-Roig C, Kotini AG, Luchsinger LL, Wei Y, Westerterp M, Snoeck HW, Papapetrou EP, Schulz C, Massberg S, Soehnlein O, Ebert B, Levine RL, Reilly MP, Libby P, Wang N, Tall AR

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice.

Cardiovascular drugs and therapy

Tang Y, Liu W, Wang W, Fidler T, Woods B, Levine RL, Tall AR, Wang N

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation.

Science signaling

Koval OM, Nguyen EK, Santhana V, Fidler TP, Sebag SC, Rasmussen TP, Mittauer DJ, Strack S, Goswami PC, Abel ED, Grumbach IM

Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes.

Diabetes

Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.

Circulation research

Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrch AS, Abel ED

Superoxide Dismutase 2 is dispensable for platelet function.

Thrombosis and haemostasis

Fidler TP, Rowley JW, Araujo C, Boudreau LH, Marti A, Souvenir R, Dale K, Boilard E, Weyrich AS, Abel ED

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

Cell reports

Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.

Arteriosclerosis, thrombosis, and vascular biology

Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.

Nature cell biology

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.

Drug metabolism and disposition: the biological fate of chemicals

Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS

Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.

Drug metabolism and disposition: the biological fate of chemicals

Madanayake TW, Fidler TP, Fresquez TM, Bajaj N, Rowland AM

Correction to "improved coiled-coil design enhances interaction with bcr-abl and induces apoptosis".

Molecular pharmaceutics

Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS

Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.

Molecular pharmaceutics

Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS